![]() ![]() Our findings indicate that, in addition to the protein content of biological secretions, their small-solute composition impacts the potency of antiviral microbicides and mucosal antibodies. Infection and inhibition in whole human seminal plasma are accurately mimicked by a stable synthetic simulant of seminal fluid that we formulated. The extraordinarily high concentration of the monosaccharide fructose in semen contributes significantly to the effect by competitively inhibiting the binding of ligands to α1,2-linked mannose residues on Env. ![]() We found that whole semen significantly reduces the potency of antibodies and microbicides that target glycans on the envelope glycoproteins (Envs) of HIV-1. However, the unstable nature of human seminal plasma and its toxic effects on cells in culture limit the ability to study in vitro virus infection and inhibition in this medium. Initial steps of transmission, including cell attachment and entry, likely occur in the presence of semen. Amazon. Alexandre Delong’s Post Alexandre Delong Directeur du Bureau des relations extrieures 20h Report this post Report Report. Read 2054 book reviews & author details and more at Amazon.in. Téluq Phone Email Jerry Delong Personal Mortgage Advisor Nations Lending Phone Email Amy DeLong Manager, Federal Government Relatio. Amazon.in - Buy 2054 book online at best prices in india on Amazon.in. Semen is the primary transmission vehicle for various pathogenic viruses. Alexandre Delong Conseiller Aux Partenariats Et à L. ![]()
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